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DOI: 10.1172/JCI5461

Cycle Length: Research protocols commonly run for 4 to 6 weeks, followed by a break of at least that long

B12 solution should be injected with air after the needle is inserted into the vial

Reported side effects are rare and generally mild: Temporary lethargy Mild swelling or irritation at the injection site Occasional digestive upset (less common with injectable forms) One area of caution: dogs with active cancer

Watch the site for excess redness, swelling, or signs of infection