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The inclusion of both reference and clinical strains enhances the translational relevance of the study and allows assessment of antimicrobial efficacy under both standardized and real-world clinical conditions

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To bridge this knowledge gap, future studies would need to focus on developing and validating already established clinically relevant animal models on large animals that better reflect human disease and allow for the study of long-term outcomes and tissue repair to set the stage for future human trials (Gonzalez et al., 2015

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