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GI side effects affect 10% to 40% of GLP-1 users, particularly during the first few weeks and during each dose escalation

The investigators posited that higher doses or different timing strategies may be necessary to see continued benefits beyond that initial increase

GR2 is dual-targeted to chloroplasts and mitochondria [117,120]

The inhibition of the cystine/glutamate transporter hinders glutathione synthesis and induces ferroptosis, a regulated form of cell death characterized by excessive accumulation of lipid peroxides

Due to the weakened ferroptosis, GC cells acquire anti-apoptotic ability and are more prone to peritoneal dissemination ( 3.2.2 Ferroptosis escape mechanisms in tumor progression To survive, cancer cells often evade ferroptosis induction through complex escape mechanisms

L., Moran, C