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Importantly, HA-344 and #231 act as specific bio-degraders of GPX4 by a currently unknown mechanism that does not seem to involve the proteasome pathway

95% CI, 13.7 to 11.7)

Mass spectrometry reports are available on request

These groups provide opportunities for individuals to connect, share stories, ask questions, and seek advice from others who are facing similar challenges

The available mechanistic information provided support for the biological plausibility of the phenotypic effects observed in exposed animals, as well as the activation of relevant molecular and cellular pathways across human and animal models in support of the human relevance of the animal findings

Abstract The SARS-CoV-2 pandemic has reemphasized the urgent need for broad-spectrum antiviral therapies