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IGF-1 influences expression of genes that regulate protein degradation, peptide processing and presentation Defects in antigen presentation have been described in PCa cell cultures 24 , involving multiple components of the APM

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[ 4 ] Instead, several hypotheses have been proposed based on preclinical investigations

It functions as a dual GIP/GLP-1 receptor agonist, meaning one peptide chain binds to and activates both the glucose-dependent insulinotropic polypeptide receptor and the GLP-1 receptor

GLP-1s are the only peptides clinically proven to help with weight loss

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