Clinical Progress of Glutaminase Inhibitors Glutaminase inhibitors selectively target the overactive GLS in cancer cells, sparing GLS2 in normal cells: Blocking EMT (Epithelial-to-Mesenchymal Transition) : These inhibitors can help prevent EMT, which supports cancer spread
More Potent: We use glutathiones most bioavailable, stable form, l-glutathione, rather than the inactive oxidized form, at a potent 1000mg dose
Makarenko VV, Usatyuk PV, Yuan G, Lee MM, Nanduri J, Natarajan V, Kumar GK, Prabhakar NR (2014) Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation
The exception is the pig e-GST that is stable only for 2 days, displaying a loss of 25% of its original activity after 7 days (Supplementary Table S2)
Revealed in the next section
A placebo-controlled trial in 40 men who had surgery to repair an inguinal hernia or hydrocele found that oral curcumin supplementation (1.2 g/day) for five days was more effective than placebo in reducing post-surgical edema, tenderness and pain, and was comparable to phenylbutazone therapy (300 mg/day) (84)
