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Iron imunomodulates the termination of the inflammatory response, as elevated Fe level increase the M2 phenotype and reduce the pro-inflammatory M1 response, reducing the IL-12/IL-10 balance

Values range from 1 to 1000, with zero representing white and 1000 representing black

Several meta-analyses described a significant reduction in the recurrence rate at medium-term follow-up, including a lower risk of surgical revision, with the use of prosthetic materials, but the quality of analyzed data was poor and therefore the results are of limited level of evidence [44,45]

Fourteen reported subjective improvement, but there was no control group, no blinded assessment, no objective functional endpoint and no follow-up imaging endpoint [5]

In this video, we emphasize that more is not always better