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Conclusion Cigarette smoking has severe long-term health effects and is responsible for millions of preventable deaths worldwide

33 METHODS Trials Overview and Participants Efficacy and safety data were pooled from the 2 phase III trials of cytisinicline 3 mg tid, the ORCA-2 and ORCA-3 studies, and the nonpsychiatric cohort from the most recent and largest phase IV trial of varenicline, the EAGLES study

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