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Acknowledgments This study was supported by the National Science Centre in Poland (2014/15/B/NZ7/00893)

2 Galano A, Alvarez-Idaboy JR

"Better" depends on individual response, tolerance, medical history, and specific metabolic goals

M., Kamel H

5 Specific enzymes in intracellular lysosomes or tumor microenvironments can selectively break the linker, for example, proteases in lysosomes hydrolyzing peptide bonds contained in dipeptide or tetrapeptide linkers, glycosidases hydrolyzing -glucuronides and -galactosides, phosphatases hydrolyzing phosphoesters and pyrophosphates, and sulfatases hydrolyzing sulfates