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These patches are often triggered by ultraviolet exposure, hormonal changes, acne, or injuries that leave behind a deposit of extra pigment

[3] It could have efficacy in preventing the development of nitrate tolerance

Although these studies do not specifically differentiate between neuronal and astrocytic contributions, it is possible that the modulation of astrocytic A 1 and A 2A receptors may have an impact on the onset and progression of ALS, given the well-established importance of astrocytes in the disease [435]

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Parkitny L, McAuley JH, Di Pietro F, Stanton TR, OConnell NE, Marinus J, van Hilten JJ, Moseley GL

By the end of study, 38 participants had remained, resulting in an 88% adherence rate

10.1016/j.arr.2003.05.001 113 SeleitI.BakryO