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The complex is eventually released from lysosomes and transported across the cell membrane bound to one of two proteins in the blood circulation: Haptocorrin, which is responsible for the transport of B 12 to the liver

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Genetic predisposition can modulate cellular sensitivity to apoptosis, and multiple regulatory factors are involved, including inflammatory mediators (IFN-, IL-2, IL-1), TSH, and anti-TPO antibodies

It is crucial for patients to be aware of the potential risks associated with these injections