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Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, Hallur MS, Kristam R, Pieper MP

5-Amino-1MQ works by precisely blocking the catalytic pocket of the NNMT enzyme

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Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+

[5] In the same 28-day study, DIO mice showed reduced body weight and fat mass gains alongside improved glucose tolerance and attenuated hepatic steatosis

Pharmaceutical pipeline: there are no Phase 1 through Phase 3 trials of 5-Amino-1MQ itself registered on ClinicalTrials.gov as of June 2026