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If the balance and, thus, the interplay of pro- and anti-inflammatory cytokines is disturbed, serious illnesses occur because either the immune defense is insufficient, or the immune reaction is excessive [9]

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Various versions of HT have been reported with various HLA alleles, including DR3, DR5, DQ7, DQB1*03, DQw7, or the DRB1*04-DQB1*0301 haplotype