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Karabakhtsian R, Broude N, Shalts N, Kochlatyi S, Goodman R, Henderson AS

The study found the peptide well-tolerated with minimal toxicity risk, though adverse events were described as mild to moderate

PMID: 34380875

GHK-Cu significantly reduced inflammatory cytokines TNF-alpha, IL-6, and IL-1beta, enhanced mucosal repair, and upregulated tight junction protein expression through inhibition of the SIRT1/STAT3 signaling pathway

[1] [9] The trial enrolled 387 adults (BMI 27 kg/m, without diabetes) and randomly assigned them 1:1:1:1:1 to once-weekly subcutaneous survodutide at 0.6, 2.4, 3.6, or 4.8 mg or placebo, with a 20-week dose-escalation period followed by 26 weeks of maintenance, for 46 weeks total