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e-cigarette users vs nonusers had the following: Younger mean age (44 vs 57 years, respectively) Lower rate of diabetes (9.8% vs 12.1%) Lower body mass index (BMI, 27.7 vs 28.1) Higher rate of cigarette smoking (78.7% vs 37.4%

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overall trends and interactions, among adults and among cigarette smokers), we compared models with survey wave analysed using restricted cubic splines with three, four, and five knots (sufficient to accurately model trends across years without overfitting) using the Akaike information criterion (AIC)

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Turkish and Balkan tobaccos sun-cured in open air produce a drier, more aromatic profile with sharper herbaceous qualities