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Among these transporters, the vacuole plays a crucial role in the accumulation and compartmentalization of metals for their detoxification

FIGURE 4 3.4 Nitazoxanide reduced apoptosis in rats with MTX-hepatotoxicity MTX significantly induced hepatic apoptosis as demonstrated by increased proapoptotic markers, Bax level, and caspase-3 activity (Figures 5A, D) while reduced antiapoptotic Bcl-2 level (Figure 5B) and increased Bax/Bcl-2 ratio (Figure 5C) compared to CTRL group

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This boost strengthens the body's defense against oxidative stress, keeping cells healthy and supporting overall well-being

To ensure the accuracy of the test results, the mice were allowed to drink normal water, and blood was collected from the tails after 12 h of fasting for the test

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