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Genet Metab

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While generating patient-specific ECs from iPSCs represents one viable strategy (201), this approach is time-consuming and may introduce genetic and epigenetic changes

F.ZhenS

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Therefore, to further dissociate the effects of GSH and NRF2 on lipid abundance and assess if NRF2 activation alone mimics the effects of liver-specific Gclc deletion, we treated Gclc WT mice with CDDO-methyl (CDDO-Me), a form of bardoxolone with increased bioavailability