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LCMS analysis was performed on a Shimadzu Prominence high-performance LC system (ExionLC) interfaced with a QTRAP 6500+ system (AB Sciex) with an iHILIC column (100 4.6 mm, 3.5 m

| Target Concentration | BAC Water to Add | Dose per 10 units on syringe | |---------------------|-----------------|------------------------------| | 5mg/ml | 2.0ml | 0.5mg | | 10mg/ml | 1.0ml | 1.0mg | **Best for:** Patients on 1-2mg weekly doses during titration weeks 1-8

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Extending the spectrum of -dicarbonyl compounds in vivo