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Our explainer on how tirzepatide influences incretin pathways and the overview at what tirzepatide (Mounjaro/Zepbound) is and how it works walk through the receptor pharmacology
SPECT studies discovered a link between putaminal uptake of dopamine transporter (DaT) tracer and poorer rigidity, in addition to more noticeable dopaminergic loss in the posterior putamen in non-TD patients and mixed subtype patients relative to TD patients [39,40]
A proposed mechanistic basis for this hypothesis is that IRS1/2 and the insulin receptor harbour inhibitory phospho-serine/threonine residues targeted by multiple kinases
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OConnor 2003)
