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Lewis et al

IL-17 is mainly secreted by T helper 17 (Th17) cells, which are elevated in the bone marrow of OVX mice with low estrogen

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Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in rats

How the human protocols are structured: Onetime gene transfer dosing (not daily injections) IM injection sites distributed through target muscles Followup over months for functional endpoints Dosing Protocol (Human clinical data only) Protocol A Becker Muscular Dystrophy (Doseescalation cohorts) Low cohort: 6 10 vg/kg total (IM

doi: 10.1016/j.molimm.2022.06.003 73 PeyssonnauxCCejudo-MartinPDoedensAZinkernagelASJohnsonRSNizetV