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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

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Early results show that IN AV enhances attention to social signals by lowering the impacts of competing goal-directed top-down attention and enhancing the importance of bottom-up processing, as evidenced in the current study utilizing an emotional anti-saccade task [125]

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