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Their complementary mechanismsvascular formation and cell migrationare being studied jointly in musculoskeletal, tendon, and ligament injury models to evaluate the synergistic effects on the speed and quality of repair

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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases