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Consequently, claims about clinical benefit should be made cautiously and framed as hypothesis-generating rather than definitive (154, 156)

For example, it can be hypothesized that upon binding to their respective receptors, IGF-1 analogs potentially trigger a cascade of biochemical events involving the PI3K pathway

Kanimozhi P, Prasad NR (2009) Antioxidant potential of sesamol and its role on radiation-induced DNA damage in whole-body irradiated Swiss albino mice

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Autophagy dysregulation in amyotrophic lateral sclerosis

Plus, most claimed benefits are based on animal studies, early research, or anecdotal reports, rather than strong human clinical evidence