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doi:10.1016/j.freeradbiomed.2008.10.040

Thus, Nrf2 induces the production of glutathione and NADPH, conferring a growth advantage to cancer cells

Decreasing the expression of key proteins in SCAP pathways induced senescent cell death, promoting the discovery of small molecules and compounds that target these SCAPs, referred to as senolytics

Hostynek JJ, Dreher F, Maibach HI

[DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted] 218.Clement E, Lazar I, Attane C, Carrie L, Dauvillier S, Ducoux-Petit M, et al

Therefore, while the exact mechanisms controlling CHAC1 expression requires further study, a significant connection to the TP53 pathway is evident