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Disclosure of interest: Sheng Yang and Alastair Webb: nothing to disclose Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, OMICS AND BIOMARKERS P1086 - ESOC25-803 ASSOCIATIONS OF MRI INDICES OF GLYMPHATIC FUNCTION AND DISEASE SEVERITY IN CADASIL Yunqing Ying 1 , Rong Zhou 1 , Xin Cheng 1 1 Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China Background and Aims: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease (CSVD)