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BCL-2 family inhibitors, such as ABT-263 (Navitoclax), induce apoptosis in senescent cells but have limitations regarding side effects and CNS penetrance

The CapnCollar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

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