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Patients should be aware that while constipation is a common side effect, it is usually manageable with lifestyle adjustments and medical guidance

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Long-term safety beyond several month treatment courses

DSIP has been investigated in controlled human sleep studies, showing effects on sleep duration, sleep stage distribution, and subjective sleep quality, making it relevant to research on sleep regulation, stress modulation, and recovery

Furthermore, combined with glutathione peroxidase 4 (GPX4)-knockdown, inhibition of DHODH by its inhibitor, brequinar, markedly suppressed xenograft tumor growth mediated by ferroptosis 47

SWS is considered deep sleep and serves a restorative function, while both REM and SWS are involved in memory consolidation [141]