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The nicotinamide acts as a feedback inhibitor of SARM1

This controlled absorption profile is fundamental to tirzepatide's once-weekly dosing schedule and its favorable efficacy and tolerability profile

So OK, the brand recommends not exceeding two uses per week (theyre playing it safe!), but personally, I think you can use it more often if your skin tolerates it well

Thymosin Alpha-1 helps modulate that whole balance

Other's on here are far more experienced than I who will cast an eye over your results and offer advice albeit they are not medics but have gone through this themselves

[DOI] [PubMed] [Google Scholar] 98.Kluger B.M., Krupp L.B., Enoka R.M