Here is the crux of the article, stated as plainly as possible: there are no published, controlled human clinical trials establishing a skin or cosmetic benefit from injected (subcutaneous) GHK-Cu
Pregnant or breastfeeding women, people with severe health conditions like chronic liver or kidney disease, and people with known allergies to any components of the injections should avoid them
Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer

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Factors affecting hydrolysis include: Storage temperature pH Amino acid sequence Buffer composition Time This is why refrigeration dramatically slows degradation
Observed responses may vary depending on research amount, administration frequency, protocol duration, physiological status, inflammatory status, and individual sensitivity