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This involves migrating neural stem cells originating from the sub-ventricular zone (SVZ) and the sub-granular zone (SGZ) of the dentate gyrus [34,342,343] to the infarct and peri-infarct region, followed by their differentiation into functional neurons [344,345,346], as shown in Figure 15 [9,12]

To engage mucosal immunity, a modified version of SmT1 was combined with the mucosal adjuvant BDX301 (named NT-CoV2-1 )