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BACH1 itself is a direct transcriptional target of HIF1A, which binds its promoter under hypoxic conditions to induce expression 174 , highlighting a multilayered transcriptional network linking hypoxia, GSH metabolism, and cuproptotic vulnerability

demonstrated that transgenic mice expressing HCV structural genes were characterized by an altered mitochondrial oxidative status

While our bodies produce glutathione naturally, factors like stress, diet, and aging can deplete its levels

In neurodegenerative diseases such as Alzheimer's disease, the aging trajectory of the brain is closely linked to various cell types, including oligodendrocyte precursor cells, glia cells, neural stem cells, neurons, and endothelia [137]

Abdel-Farid IB, Jahangir M, Mustafa NR, Van Dam NM, Van den Hondel CA, Kim HK, Choi YH (2010) Verpoorte R.: glucosinolate profiling of Brassica rapa cultivars after infection by Leptosphaeria maculans and Fusarium oxysporum

doi: 10.1016/j.atherosclerosis.2007.05.012