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Elevated levels of oxidative stress markers have been consistently reported in ME/CFS, including malondialdehyde (MDA), isoprostanes, 8-OH-deoxyguanosine, 2,3 diphosphoglyceric acid, thiobutyric acid, and protein carbonyls

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A 2015 Scientific Reports study comparing six commercial kits found inter-assay variations of 5-20%, highlighting the need for consistent methodology when tracking changes over time