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Mitochondrial rescue Prevents Glutathione Peroxidase-dependent Ferroptosis

Lim, E.-K

Previous studies have found that the SARS-Cov-2 spike protein is associated with increased oxidative stress and reactive oxygen species within PBMCs [30]

It is known that, in rat and human GLCL holoenzyme, cystamine completely inactivates rat GLCL activity by interaction with a thiol group that is thought to be at or near the l-glutamate-binding site in the wild enzyme [135,136,137,138] and also in a recombinant mutant (hGLCLC-C553G) where one cysteine group far from the active site was selectively inactivated [139]

In addition, the results obtained in cells expressing HPV-16 E7 Mut clearly highlighted the substantial role of the physical interaction between the oncoprotein and GSTP1 in modulating its anti-apoptotic, JNK-mediated activity

Hence, the requirement of taking informed consent does not arise