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Theca cells are very sensitive to the gonadal steroid gonadotropin, which cause hyperandrogenism in PCOS patients (56)

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4.2 Primary ovarian insufficiency Primary ovarian insufficiency (POI), historically referred to as premature ovarian failure (POF), affects 1%3% of women under 40 and arises from accelerated follicular loss or dysfunction (Touraine et al., 2024)

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