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119 Research indicates that factors such as age, diet, alcohol consumption, fructose-rich intake, pharmacologic interventions and diseases, such as obesity, insulin resistance, Down syndrome, and kidney disease, contribute to the development of hyperuricemia 120,121,122,123,124 (Fig

13 C 6 -Glucose tracing metabolomics Cells were cultured in complete NB medium (1 10 6 cells/T-25 flask), without D-glucose supplemented with 4.5 g/L 13 C 6 -glucose (Sigma) and incubated at 37 C for 24 h

As GSH cannot readily cross the cellular membrane due to its biochemical properties 35 , we assume that GSH excretion is negligible and do not account for it in the equation

All patient primary diagnosis slides were reviewed by a single pathologist (E.E.) to confirm primary epithelial ovarian cancer diagnosis