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Eight weeks of aerobic exercise significantly activated the System Xc /GPx4 signaling pathway in the prefrontal cortex of APPswe/PS1dE9 transgenic AD mice, up-regulated FTL and BACE1 expression, significantly downregulated 4-HNE levels, inhibited oxidative stress, lipid peroxidation, and ferroptosis, reduced A positivity, alleviated neuronal morphological abnormalities, and improved learning and memory functions in AD mice (Li et al., 2024a)

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Antioxidants (2016) 6:1

Disorganized neovessels and uneven perfusion generate regions of chronic hypoxia and acidosis [12, 15]

then, in the remodeling stage, collagen is reorganized, and thus the structure and functions of the skin are restored [159]

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