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These CS-induced EVs had no obvious effect on the number and cytokine production (TNF, IL-6, IL-23) of dendritic cells, as well as the polarization of M0 macrophages, but they acted as a proinflammatory factor that induced osteoclastogenesis by inhibiting cyclooxygenase-2 (COX-2), revealing a mechanism of CS signaling and offering a potential target for therapeutic interference of inflammatory disease [99]
Toxicol in Vitro 28 , 198208 (2014)
These inconsistencies may be due to a range of factors: Variations in study design and methodology Differences in how testosterone is measured (total vs free testosterone) Confounding variables such as age, BMI and alcohol consumption The dose and duration of smoking exposure So, Does Smoking Truly Boost Testosterone