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However, long-term use of high concentrations, large-area topical applications, or injectable administration may increase the potential risk of copper accumulation in skin tissues

This method delivers the peptide directly into the bloodstream or near the site of injury

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doi: 10.1080/15592324.2025.2486076 73 JadhavPAThomasABPathanMKChaudhariSYWavhaleRDChitlangeSS

These structural features improve peptide stability , extend half-life , and reduce amyloid fibril formation relative to native amylin, supporting sustained activity in experimental systems