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It is characterized by slow brain waves (0.5-4 Hz) and is associated with physical recovery, memory consolidation, and growth hormone (GH) secretion

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Hoffman M, Chansky PB, Bashyam AR, Boettler MA, Challa N, Dominguez A, et al

With direct hGH injections, especially at high doses, theres a risk of excessively elevated GH/IGF-1 levels, which may lead to side effects like joint pain, edema, insulin resistance, or carpal tunnel syndrome

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Immunol Rev 246(1):125140 Sun Z, Gong W, Zhang Y, Jia Z (2020) Physiological and pathological roles of mammalian NEK7