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This starts the functional sequence of the HPT axis ( Figure 1 ) (Nillni, 2010)

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69 World Health Organization

Thalassaemia-A global view

Research Context This stack pairs two distinct families of growth-hormone-axis research peptides in a single lyophilised vial: CJC-1295 (no-DAC variant, also known as Modified GRF 1-29), a 29-residue tetrasubstituted analogue of the first 29 residues of growth-hormone-releasing hormone (GHRH), and Ipamorelin, a synthetic 5-residue pentapeptide classified as a growth hormone secretagogue (GHS) that acts via the ghrelin receptor (GHS-R1a)