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Second, GLP-1 secretion by engineered bacteria does not recapitulate the physiologically pulsatile release pattern of native L-cells, which depends on nutrient-derived stimuli, Ca 2+ signaling, and coordinated enteroendocrine regulation ( 10 Conclusion Current evidence indicates that the functional heterogeneity and adaptive potential of -cells in T2D are shaped by both intrinsic molecular programs and extrinsic regulatory cues, among which signals originating from the gut microbiota are particularly prominent

The stability of mitochondrial membrane potential promotes the preservation of normal cellular physiological function

Liver Int 23 , 405409 (2003)

Also, WoLFPSORT predicted three antigens to be localized in the extracellular space (A0A0K0EG68, A0A0K0EMX1, and A0A0K0ELA9) while two antigens (A0A0K0E6J0 and A0A0K0EKU6) were localized in the mitochondrion and endoplasmic reticulum

Cobo-Ibez T, Urruticoechea-Arana A, Ra-Figueroa I, et al

Eduardo Ruvolo, MS