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And a naturally occurring copper peptide called GHK-Cu might be exactly that signal

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Abbreviations CM: Citrulline malate NO: Nitric oxide ATP: Adenosine triphosphate MAS: Malate aspartate shuttle MDH: Malate dehydrogenase NIRS: Near infrared spectroscopy PFK: Phosphofructokinase TCA: Tricarboxylic acid HR: Heart rate GI: Gastrointestinal GVT: German volume training VO 2peak : Peak oxygen consumption EMG: Electromyography References Agudelo LZ, Ferreira DM, Dadvar S, Cervenka I, Ketscher L, Izadi M, Ruas JL (2019) Skeletal muscle PGC-11 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

PK describes how the body absorbs, distributes, metabolizes and eliminates the compound (ADME)