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To investigate this rebound period, mice were exposed to CS for 5 hours and then allowed to rest in a room receiving filtered air for 0, 2, 4, 8, or 16 hours

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Some of the neurobiological factors theoretically associated with depression are the activation of the inflammatory system, hypothalamic-pituitary-adrenal axis disturbances, dysfunctional neuroanatomic circuits (particularly the default mode network), abnormal neural activity, neurotransmitter dysfunction, polymorphisms in the 5-HTT promoter region (5HTTLPR) and interactions between brain derived neurotrophic factor (BDNF)

Anal Chem 86:1020110207