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For instance, the combination of inhibitors targeting the PI3K/Akt pathway with paclitaxel drugs has been shown to enhance the sensitivity of paclitaxel (109)

McTiernan, N., Kjoss, I., & Arnesen, T

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Crosstalk between different cell death pathways may also be related to resistance to targeted therapy, and the induction of different types of cell death, such as ferroptosis, through targeted therapy has become a new strategy in kidney cancer treatment (139)