In ccRCC, a hallmark is the accumulation of lipid- and glycogen-rich cytoplasmic dropletsa trait largely driven by loss of VHL function and subsequent stabilization of hypoxia-inducible factors (HIFs)
The ELF GSH levels that occur with the initial adaptive response are roughly 500-600 M (Figure 1A and 4A) while the GSH levels for the maintained adaptive response over repeated CS exposures are only about 250-300 M (Figure 1A)
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Isolated circles represent all observations (in triplicates) below the 10th percentile or above the 90th percentile
As expected, erastin caused a dramatic decrease in GSH, leading to a decrease in the GSH/glutathione disulfide (GSSG) ratio (Fig
In a laboratory setting, it functions as a biochemical tool used to study peptide stability, degradation profiles, and cellular interactions in isolated environments