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Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71

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The compound then received GRAS (Generally Recognized as Safe) designation from the FDA for use as a food ingredient, which is a separate regulatory category from drug approval

Disclaimer: This product is intended for laboratory research use only (RUO)

Bethesda (MD): National Institutes of Health (US)

The consistency of this finding across multiple independent trials, different dose ranges, and various administration routes provides robust evidence that the peptide does not affect the growth hormone/IGF-1 axis