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Determination of glutathione reductase (GR) activity The glutathione-mediated NADPH oxidation was monitored to analyze GR activity at OD412 nm using the GR Assay Kit (Cat#S0055, Beyotime, Haimen, China) according to the manufacturer instructions

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53,54 However, it has also been suggested that the enhanced release of proinflammatory cytokines (TNF-, IL-1, IL-6, and IL-10) and chemokines (monocyte chemoattractant protein-1, macrophage inflammatory protein-2, and IL-8) further promotes hepatocyte damage, thereby aggravating necrosis

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