10.1001/jamaneurol.2018.0821 JAMA Neurol
Additionally, -SMA + CAFs secret a range of cytokines, such as M-CSF, IL-6, IL-8, IL-10, TGF-, and CCL-2, inducing macrophage differentiation and M2 polarization that contributes to immunosuppressive TME [63,64,65]
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Excessive secretion of corticotropin-releasing hormones (CRH) in patients with depression increases CRH in the blood, cerebrospinal fluid, and metabolites, which downregulate the CRH receptor and cause the loss of the action site of excessive secretion of CRH, resulting in a vicious cycle of increasing CRH in the body and eventually producing depressive symptoms [107]
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