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98 , 99 Then, the hydrophobic C-terminal of AMP may insert into the hydrophobic region of the cell membrane, which may change the conformation of the cell membrane and reduce the activity of P-gp by inhibiting the efflux of chemotherapy drugs, increasing the intracellular drug concentration, and reversing drug resistance of MDR tumor cells

He is not taking any medications

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This restoration of stem cell function represents a fundamental mechanism for maintaining tissue health and function throughout the aging process, potentially extending both healthspan and physical independence in older populations

*Correction*: since publishing this article, people have pointed me to grey market sources of klotho that are research grade