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Interaction 2 Nicotine Speeds Caffeine Clearance Smokers metabolise caffeine twice as fast as non-smokers Nicotine induces liver enzymes (CYP1A2) that significantly accelerate caffeine metabolism smokers clear caffeine from their system approximately twice as fast as non-smokers

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The first visual warnings were introduced on cigarette packs in Canada in 2000

Early symptoms of lung cancer include: Shortness of breath Persistent cough Weight loss Coughing up blood Chest and lung pain These symptoms may continue or get worse as the cancer progresses into a later stage

Sunburn, a clear indication of overexposure to UV radiation, is a preventable risk factor for skin cancer and those events occurring in childhood pose some of the greatest risk (107)